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KMID : 1035620140020050394
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Allergy Asthma & Respiratory Disease
2014 Volume.2 No. 5 p.394 ~ p.397
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Successful desensitization for cytarabine induced anaphylaxis
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이현우:Lee Hyun-Woo
박재용:Park Jae-Yong/문준호:Moon Joon-Ho/박경택:Park Kyung-Taek/박한기:Park Han-Ki/강혜련:Kang Hye-Ryun
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Abstract
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Cytarabine is a very important chemotherapeutic agent for leukemia and lymphoma patients and is prescribed more frequently than before. Cytarabine-induced delayed-onset hypersensitivity may rarely present as non-IgE mediated anaphylaxis. However, we do not know yet whether desensitization therapy in adults may be effective in cytarabine-induced delayed-onset anaphylaxis. A 78-year-old woman who was diagnosed with acute myeloblastic leukemia had chemotherapy including cytarabine. In spite of premedication with hydrocortisone and chlorpheniramine, the patient had anaphylaxis a few hours after cytarabine infusion. We decided to perform desensitization therapy. After desensitization therapy using a newly designed protocol, the patient was tolerable to cytarabine infusion without hypotension or high fever. Desensitization therapy was successfully performed on an adult patient with delayed-onset anaphylaxis caused by cytarabine.
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KEYWORD
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Anaphylaxis, Cytarabine, Immunologic desensitization
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